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apalutamide will decrease the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs which have been CYP3A4 substrates may lead to lessen publicity to these drugs.Utilizing this medicine with any of the s